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Abstracts on Oxalosis and pulmonary aspergillosis
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Journal de Mycologie Medicale (2007) 17, 122—125 |
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Oxalosis and necrotizing pulmonary aspergillosis:
About two cases |
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I. Chtourou a, I. Bahri Zouari a,*, N. Gouiaa a, I. Fakhfakh a,
S. Charfi a, A. Hadj Kacem b, T. Sellami Boudawara a |
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a Laboratoire d’anatomie et de cytologie pathologiques, CHU Habib-Bourguiba, Sfax, 3029 Tunisie
b Service de chirurgie thoracique et cardiovasculaire, CHU Habib-Bourguiba, Sfax, 3029 Tunisie |
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Pulmonary oxalosis is a very rare pseudotumoral lesion; it is often secondary to an
infection by Aspergillus niger and more rarely by A. flavus, A. fumigatus, A. luchurensis or by
Beauveria bassiana. Here, we report two cases of chronic necrotizing pulmonary aspergillosis
associated with oxalosis in two patients, a 17-years-old youth and a 69-years-old man with a
history of tuberculosis. The diagnosis was based on histological examination of the surgical
specimens highlighting the birefringent calcium oxalate crystals by polarization associated with
branching septate hyphae. The culture yielded A. niger for the younger patient. Our aim is to
discuss the diagnosis and the histogenesis of this pathologic association. |
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Pathology – Research and Practice 201 (2005) 363–368 |
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Aspects of oxalosis associated with aspergillosis in pathology specimens |
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Ugur Pabuccuoglu |
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School of Medicine, Department of Pathology, Dokuz Eylu¨l University, Inciraltı-Izmir, Turkey |
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Oxalosis (calcium oxalate deposition) is associated with various conditions, including aspergillosis. Some Aspergillus
species produce oxalic acid, which reacts with blood or tissue calcium to precipitate calcium oxalate. Calcium oxalate
crystals exhibit various shapes and are strongly birefringent. These occur in cytological specimens, as well as in tissues
of patients with Aspergillus infection. Aspergillus species are hyaline septate moulds, and they can be accurately
recognized in pathology specimens only if conidial heads (fruiting heads) are present. When these structures are not
observed, detection of associated oxalosis in a mould infection supports the pathological diagnosis of aspergillosis. The
presence of oxalosis is helpful when microbiological identification or immunohistological techniques for fungi are not
available. Calcium oxalate crystals can induce cellular injury by several mechanisms, and there is increasing evidence
that oxalosis-induced tissue damage may occasionally lead to a poor clinical outcome. This review discusses the
diagnostic value and the potential clinical significance of oxalosis associated with aspergillosis. |
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Chest 1992;101;870-872 |
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Invasive Aspergillus niger with fatal pulmonary oxalosis in chronic obstructive pulmonary disease |
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EA Kimmerling, JA Fedrick and MF Tenholder |
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The ubiquitous Aspergillus fungus has numerous manifestations when associated with lung disease (primary Aspergillus pneumonia, aspergilloma, allergic bronchopulmonary aspergillosis, and invasive Aspergillus). This fungus
also can colonize preexisting lung disease in an indolent
manner and then acutely assume a more invasive nature.
Although the species Aspergillus niger is infrequently
encountered, the endobronchial visualization of black necrotic debris or a fungus ball or the finding of black acidic
sputum or pleural fluid suggests the presence of A niger
and the destructive by-product of its fermentation, oxalic
acid. |
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Mycopathologia Volume 73, Number 1 / January, 1981 |
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Oxalosis associated with an Aspergillus niger fungus ball. Report of a case |
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C. Severo1, A. T. Londero1 , G. R. Geyer1 and P. D. Picon1 |
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(1) Hospital Sanatório Partenon, 90000 Porto Alegre, RS, Brazil |
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(2) Tuiuti 1809/201, 97100 Santa Maria, RS, Brazil |
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During a seventeen day period an A. niger fungus ball evolved within a healed tuberculous cavity of a patient. Symptoms were a cough with a chocolate brown expectoration and dyspnea. The patient died and necropsy was performed. Crystals of calcium oxalate were deposited in the cavity lining and in the adjacent tissue of the lung. Fibrosis, mononuclear infiltration and intraalveolar purulent exudate were seen in these tissues. Some small vessels presented recent thrombosis and deposition of calcium oxalate. The bronchus connected with the cavity presented a disrupted epithelial layer, edema, polymorphonuclear infiltration and birefringent crystals. Scattered areas of tubular atrophy, glomerular sclerosis and lymphoid infiltration were seen in the cortex of the kidney. Oxalate crystals were also seen within the renal tubuli. |
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