1: Br J Oral Maxillofac Surg. 2004 Apr;42(2):173-5.

Peripheral dentinogenic ghost cell tumour presenting as a gingival mass.

Wong YK, Chiu SC, Pang SW, Cheng JC.

Oral-Maxillofacial Surgery and Dental Unit, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong, ROC. wykj@graduate.hku.hk

A 71-year-old man presented with a gingival mass at an extraction site. The lesion was initially thought to be a peripheral ameloblastoma on incisional biopsy. It was finally diagnosed as dentinogenic ghost cell tumour after excision with a margin of sound bone. There has been no recurrence after 2 years

 2: Int J Oral Maxillofac Surg. 2002 Dec;31(6):684-7.

A recurrent case of odontogenic ghost cell tumour of the mandible.

Kasahara K, Iizuka T, Kobayashi I, Totsuka Y, Kohgo T.

Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University, Japan. kasahara@den.hokudai.ac.jp

Odontogenic ghost cell tumour (OGCT), also referred to as dentinogenic ghost cell tumour, is an extremely rare tumour classified as a neoplastic variant of calcifying odontogenic cyst (COC). To date, only 13 cases of OGCT arising in the maxilla or mandible have been reported. We describe an OGCT that recurred after segmental resection of the mandible in a 59-year-old man. Histopathological examination revealed tumour invasion of the surrounding cortical bone, areas containing numerous calcifying flaky cell nests, and dentinoid matrix near epithelial cell nests. No atypical mitosis was found. There has been no evidence of recurrence or metastasis in the 4 years after operation.

3: Oral Oncol. 2000 Jan;36(1):134-43.

Dentinogenic ghost cell tumor: histologic aspects, immunohistochemistry, lectin binding profiles, and biophysical studies.

Mori M, Kasai T, Nakai M, Sato K, Takeuchi H, Takai Y, Kanematsu N.

Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry, Gifu, Japan. os@dent.asahi-u.ac.jp

Dentinogenic ghost cell tumor accompanied with calcifying odontogenic cyst (COC) was described in terms of its clinical, histological, immunohistochemical, lectin binding and biophysical properties. The case was a 38-year-old Japanese female, in whom the tumor had arisen in the right mandibular premolar and molar region. Material obtained by partial mandibulectomy was used. Decalcified paraffin sections were used to detect keratins, involucrin, and lectin binding; and non-decalcified thin sections were used for biophysical analysis. The lesion comprising dentinogenic ghost cell tumor and COC contained odontogenic epithelium with ghost cells, eosinophilic amorphous materials and osteodentin. Some of the eosinophilic material had undergone transformation into osteodentin. Keratins in odontogenic epithelia showed positive PKK1 staining in peripheral tumor cells, and stainings with KL1 and involucrin were positive in centrally located cells. Lectin binding in the amorphous materials was comparatively strong for PNA, and SBA, moderate for WGA, RCA-1, and UEA-1, and slight for DBA and ConA. Lectin binding affinities were higher in the amorphous materials than in the osteodentin. Elemental analysis with an electron probe X-ray microanalysis of the amorphous materials and osteodentin showed a pattern similar to that found in the normal dentin. The biologic properties of the eosinophilic amorphous materials suggested the material to be poorly calcified osteodentin, which gradually transformed into the well-calcified type.

4: Oral Oncol. 1998 Nov;34(6):502-7

Immunohistochemical analysis of a dentinogenic ghost cell tumour.

Piattelli A, Fioroni M, Di Alberti L, Rubini C.

Dental School, University of Chieti, Italy. apiattelli@unich.it

A dentinogenic ghost cell tumour in an 80-year-old male patient is presented. It is an extremely rare tumour and only 10 cases have been reported in the English literature. The lesion showed odontogenic epithelium, ghost cells, dentinoid, giant cells. The immunohistochemical analysis for Mib-1 and bel-2 showed a strong positivity of the cells of the odontogenic epithelium, while with p53 only a rare positivity was observed. Completely negative were the ghost cells, giant cells and dentinoid material. In this tumour the cells expressing Mib-1 and bcl-2 could be the cells that proliferate, and that could undergo malignant transformation

5: J Oral Pathol Med. 1992 Feb;21(2):93-5.

Peripheral dentinogenic ghost cell tumor.

Raubenheimer EJ, van Heerden WF, Sitzmann F, Heymer B.

Department of Oral Pathology, Medical University of Southern Africa, Medunsa.

A case of dentinogenic ghost cell tumor, that has originated peripherally in the jaw, is presented and the literature reviewed with particular reference to the origin of the tumor. The total number of central and peripheral cases reported in the English literature is 10 and although mucosal infiltration is common, peripheral origin of the neoplasm could be verified in only 3 cases.

6: J Oral Pathol Med. 2005 Sep;34(8):511-2

Ameloblastoma ex calcifying odontogenic cyst (dentinogenic ghost cell tumor).

Ide F, Obara K, Mishima K, Saito I.

Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. ide-f@tsurumi-u.ac.jp

Calcifying odontogenic cyst (COC) has shown to be of extensive diversity in its clinical and histopathological features, as well as in its biological behavior. In this report, a rare case is described of ameloblastoma ex COC (dentinogenic ghost cell tumor) and the relevant literature is briefly reviewed.