School of Myology - Workshop - Class 2002

Case No. 10

Clinical Setting

Male adult 25 yo. Progressive muscular weakness predominantly in lower limbs. CK: 5000 U.

Pathology

Microscopy

Dystrophic changes are observed on HE stain (fiber necrosis, regeneration, endomysial fibrosis)

Same changes are noted on Gomori stain.

Mosaic membrene expression pattern in immunohistochemistry with antibodies for dystrophins.

Positivity to antibodies for different sarcoglycans (alpha slightly decreased),

and laminins.

Proposed diagnosis

Muscular dystrophy, Becker's

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