Lymphnodes examined from pyloric and lesser curvature regions

Lyphnodes have a preserved architecture with patent subcapsular sinuses.

Higher power on the sinuses disclose atypical clusters of cells.

These cells have a vacuolar cytoplasm. 

Immunohistochemistry, Cytokeratins, demonstrate sinus neoplastic emboli.

Sinuses are filled with carcinomatous cells, less apparent on HE stain.

Carcinomatous cells should not be confused with muciphages, cytokeratin negative, sometimes encountered in the sinuses.

References